July 2005, SynChron
SynChron: Ultra-Rapid Thermal Cycler
Introducing the worlds fastest thermal cycler, capable
of completing a 35 cycle 113 bp amplification in as little
as 6 minutes!
Integrated Thermal Control (ITC), the basis of this advance,
makes the tube itself the heater element. This allows
peak temperature ramp rates of 50ºC per second, meaning
a cycle can be completed in as little as 10 seconds.
Additionally, each tube has its’ own temperature sensor,
ensuring each well remains within 0.1ºC of its’
target temperature, completely removing the possibility
of “edge effects” and well-well temperature
variation.
Equally important is the flexibility of the system, supplied
in a convenient 96 well format. Each tube can be individually
controlled allowing multiple tests to be completed in a
single 10 minute run. Optimisations can also be carried
out in a similar fashion as 96 completely different profiles
can be run at once.
The most marked benefit to the user is the improvement
in quality of the resulting product. As less time is spent
at deleterious temperatures-there are markedly fewer primer
dimers and spurious products, meaning a clearer result every
time.
