March 2006, SoftGenetics - Automated Methylation State Analysis
Module
Introducing the latest advancement in the Mutation
Surveyor sequence analysis package:
Automated methylation state analysis;
There is a new analysis type for the Mutation Surveyor
package that allows the methylation state of the sequenced
DNA to be established following bisulfite treatment. Essentially,
the software is able to compare the sequenced DNA to the
published Genbank sequence and search for the substitutions
introduced following bisulfite treatment of unmethylated
DNA, thereby allowing the methylated areas of the DNA to
be deduced.
For further information please see the Mutation Surveyor
section of our website.
For new users;
Mutation Surveyor is a powerful sequence analysis tool
that, unlike other software packages, performs an actual
trace-to-trace comparison of your sequencing analyses. This
allows accurate detection of, for instance insertions and
deletions as the software is using the actual data set as
opposed to a simple text based comparison system. The software
allows rapid comparison of up to 400 sequences to be compared
in a single run, via a simple to use graphical interface.
For those groups routinely performing fragment length analyses,
we also have a package that is able to rapidly analyse 400
data sets in a single run. Gene Marker features support
for all standard fragment length analyses, but with additional
pedigree, MLPA and AFLP segments included- allowing users
to perform all their analysis in a single easy to use package.
Both Mutation Surveyor and Gene Marker can analyse
data from any sequencing instrument.
For more details, download the Mutation
Surveyor Sequence Analysis Package PDF 
(141Kb)
